We gathered.

What is it about? This review synthesizes 21st-century evidence on trends in autism prevalence and youth suicide, and examines research linking autism to suicidality. It also discusses how psychedelics—through effects on serotonergic and glutamatergic systems—might be neurobiologically...

What is it about? This study examines whether melancholic features affect how well a single low-dose ketamine infusion (0.5 mg/kg) reduces suicidal thoughts in people with treatment-resistant depression and severe suicidal ideation (TRD-SI). Ketamine is known to rapidly reduce suicidality, but...

What is it about? This article examines the emergence of the psychedelic humanities as an interdisciplinary field spanning anthropology, history, philosophy, and science and technology studies. Langlitz analyzes how humanities scholars engage with psychedelic substances, research practices, and...

What is it about? In this essay, Nicolas Langlitz argues that books can function as extrapharmacological factors—non-chemical influences that shape the subjective effects of psychoactive substances. Drawing on the history of psychopharmacology, psychedelic research, and anthropology, he...

What is it about? This study investigates whether a single infusion of low-dose ketamine is associated with changes in brain network integrity in patients with treatment-resistant depression (TRD) and suicidal ideation. Using resting-state functional MRI and graph theory–based network metrics,...

What is it about? This study investigates whether low-grade inflammation influences the rapid antidepressant and antisuicidal effects of low-dose ketamine in patients with treatment-resistant depression (TRD). Using pooled data from three clinical trials, treatment outcomes were compared...

What is it about? This paper proposes a framework for evaluating hypotheses about the neural correlates of consciousness (NCCs) by treating them not merely as statistical correlations, but as testable claims that support predictions about conscious experience. The author introduces “sufficiency...

What is it about? This article explores “acid empiricism” as a philosophical framework for understanding psychedelic experience, particularly experiences induced by LSD. Drawing on traditions in empiricism, phenomenology, and philosophy of mind, the author examines how altered states of...

What is it about? This study examines whether a single infusion of low-dose ketamine is associated with changes in thalamocortical functional connectivity (resting-state connectivity between the thalamus and cortical regions) in patients with treatment-resistant depression (TRD), including a...